Epigenetic regulation of centromeric chromatin: old dogs, new tricks?

By Robin C. Allshire, G. Karpen. Nature reviews genetics, 2008

595 citations recorded by the source corpus.

The assembly of just a single kinetochore at the centromere of each sister chromatid is essential for accurate chromosome segregation during cell division. Surprisingly, despite their vital function, centromeres show considerable plasticity with respect to their chromosomal locations and activity. The establishment and maintenance of centromeric chromatin, and therefore the location of kinetochores, is epigenetically regulated. The histone H3 variant CENP-A is the key determinant of centromere identity and kinetochore assembly. Recent studies have identified many factors that affect CENP-A localization, but their precise roles in this process are unknown. We build on these advances and on new information about the timing of CENP-A assembly during the cell cycle to propose new models for how centromeric chromatin is established and propagated.

Subfields: Genetics, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/eb589b84ae62b6f55eacaa8357c9e8ac5d384d09

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Aline V. Probst
2. S. Erhardt
3. G. Almouzni
4. Elaine M. Dunleavy

In Molecular Biology

1. Aline V. Probst
2. S. Erhardt
3. Stephen S. Taylor
4. G. Almouzni
5. Elaine M. Dunleavy

Citations in the corpus

• Repetitive centromeric satellite RNA is essential for kinetochore formation and cell division (2014, background): “Many mechanisms and factors of CENP-A regulation and deposition in flies have been identified (Allshire and Karpen, 2008; Erhardt et al., 2008; Orr et al., 2010; Bade et al., 2014; Chen et al., 2014; Mathew et al., 2014), but emerging observations from other organisms suggest that noncoding RNAs…”
• Histone variants — ancient wrap artists of the epigenome (2010, unknown): “We do not discuss histones that occupy linker DNA between nucleo somes, such as H1, or attempt to duplicate the work of many excellent reviews of the extensive literature on particular variants 3–9 .”
• The spindle assembly checkpoint. (2012, background): “Centromeric chromatin is specified by nucleosomes with the histone H3 variant CENP-A [25], which recruits the constitutive centromere-associated network (CCAN), a complex of at least 16 different proteins [23,24].”
• HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. (2009, unknown): “In addition, although it does not localize to centromeres, a NASP-(N1/N2)-related protein Sim3 interactswithCnp1( S.pombe CenH3)andisrequiredforitsdepo-sition at centromeresinfission yeast (Dunleavy et al., 2007).”
• Epigenetic inheritance during the cell cycle (2009, background): “The histone H3 variant CENP-A marks the site of centromere identit”