Histone variants — ancient wrap artists of the epigenome

By Paul B. Talbert, Steven Henikoff. Nature reviews. Molecular cell biology, 2010

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A double take on bivalent promoters. (2013, background): “Unlike canonical histones, which are synthesized and deposited in a strictly replication-coupled fashion during S phase, histone variants are expressed throughout the cell cycle and can be deposited independently of DNA replication (Sarma and Reinberg 2005; Talbert and Henikoff 2010).”
The Honey Bee Epigenomes: Differential Methylation of Brain DNA in Queens and Workers (2010, background): “Interestingly, histone variants have been implicated in multiple conserved roles in eukaryotes [18] and therefore are part of the cellular maintenance systems together with other ubiquitously expressed genes.”
Interpreting thelanguage of histone and DNA modifications (2014, background): “The degree to which chromatin is organized and packaged is highly influenced by numerous factors, including the actions of linker histone H1 that regulates the formation of higher-order chromatin states [6], histone variants that can be substituted for canonical histones in the nucleosome core parti”
Regulation of nucleosome dynamics by histone modifications (2013, neutral): “The properties of nucleosomes can be altered in several ways, including the replacement of canonical core histones with specialized variants 2 , repositioning or evic-tion of histones from DNA by ATP-dependent chromatin remodeling enzymes 3 and, the topic of this Review, covalent modification of…”