Microglia and macrophages in brain homeostasis and disease

By Qingyun Li, B. Barres. Nature reviews. Immunology, 2017

1,725 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/89cc0a9647c1321c47810ac3be02ac189dd60e22

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. Chao Gao
2. Shengdi Chen
3. Yuyan Tan
4. Jingwen Jiang
5. B. Barres
6. M. Sofroniew

In Immunology

1. A. Mantovani
2. M. Locati
3. Chao Gao
4. Shengdi Chen
5. Yuyan Tan
6. Jingwen Jiang
7. G. Curtale
8. T. Wyss‐Coray

In Neurology

1. Chao Gao
2. Shengdi Chen
3. Yuyan Tan
4. Jingwen Jiang
5. B. Barres
6. Qingyun Li
7. L. Clarke
8. T. Wyss‐Coray

Citations in the corpus

• Developmental heterogeneity of microglia and brain myeloid cells revealed by deep single-cell RNA sequencing (2018, positive): “Microglia and most other tissue macrophages are long-lived, self-renewing cells that are generated by waves of erythro-myeloid progenitors in the yolk sac, independently of bone marrow-derived cells (Gomez Perdiguero et al., 2015; Hoeffel et al., 2015; Li and Barres, 2017).”
• Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023, methodology): “41 ORIGIN AND DEVELOPMENT OF BRAIN MICROGLIA Microglial cell colonization of the CNS is evolutionarily conserved across vertebrate species and occurs before the formation of the neuroectoderm-derived glial cell types such as oligodendrocytes and astrocytes.”
• ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020, background): “In response to these stimuli, microglia mediate both protective and deleterious responses to brain insults and so are critical regulators of the immune response in neurodegenerative disease (reviewed in [11]).”
• Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “They continuously survey the brain parenchyma to detect any alterations in their microenvironment.(302,304,305) Since it can reduce inflammation, it is beneficial for dead and dying neurons to undergo phagocytosis.”
• Diversity, Mechanisms and Significance of Macrophage Plasticity (2019, background): “For instance, brain mononuclear phagocytes include in addition to microglia, perivascular, meningeal and choroid plexus macrophages and single cell analysis has further dissected the diversity of brain phagocytes (17; 18).”
• Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “Neuroinflammation, characterized by a high level of pro-inflammatory cytokine production and glial cell activation, is a common feature of many neurodegenerative diseases [197].”