Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo.

By O. Farokhzad, Jianjun Cheng, Benjamin A. Teply, I. Sherifi, S. Jon, P. Kantoff, J. Richie, Robert Langer. Proceedings of the National Academy of Sciences of the United States of America, 2006

1,672 citations recorded by the source corpus.

Subfields: Biomaterials, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/eb4565b9d38a22a654664caaac01870b54298156

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Citations in the corpus

Interactions of nanomaterials and biological systems: implications to personalized nanomedicine (2012, background): “In a mouse xenograft model, one single intratumoral injection of aptamer-functionalized nanoparticles loaded with docetaxel was able to show a considerably higher proportion of complete tumor regression and significantly prolonged survival rates [90].”
Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies. (2016, methodology): “eliver a minimal dosage of cisplatin specifically to prostate caner cells with greater efficacy than free cisplatin (Dhar et al., 2008; arokhzad et al., 2006).”
Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform. (2008, methodology): “9 In addition, the preparation of polymeric NPs based on the nanoprecipitation or double emulsion methods is simple and scalable.(7) For example, Genexol-PM is a NP formulation of paclitaxel and poly(D,L-lactide)-bpolyethylene glycol-methoxy, which has been approved for metastatic breast cancer ther”
Biodegradable luminescent porous silicon nanoparticles for in vivo applications (2009, background): “Many biodegradable polymeric nanoparticles that can encapsulate hydrophilic or hydrophobic drugs have been developed for in vivo therapeutic application”
Innovative approaches for cancer treatment: current perspectives and new challenges (2019, background): “[143] reported that the use of A10 RNA aptamer conjugated to docetaxel-loaded nanoparticles significantly enhances in vitro cytotoxicity.”