Biodegradable luminescent porous silicon nanoparticles for in vivo applications

By Ji-Ho Park, Luo Gu, G. von Maltzahn, Erkki Ruoslahti, Sangeeta N. Bhatia, Michael J. Sailor. Nature Materials, 2009

1,761 citations recorded by the source corpus.

Nanomaterials that can circulate in the body hold great potential to diagnose and treat disease1–4. For such applications, it is important that the nanomaterials be harmlessly eliminated from the body in a reasonable period of time after they carry out their diagnostic or therapeutic function. Despite efforts to improve their targeting efficiency, significant quantities of systemically administered nanomaterials are cleared by the mononuclear phagocytic system before finding their targets, increasing the likelihood of unintended acute or chronic toxicity. However, there has been little effort to engineer the self-destruction of errant nanoparticles into non-toxic, systemically eliminated products. Here, we present luminescent porous silicon nanoparticles (LPSiNPs) that can carry a drug payload and of which the intrinsic near-infrared photoluminescence enables monitoring of both accumulation and degradation in vivo. Furthermore, in contrast to most optically active nanomaterials (carbon nanotubes, gold nanoparticles and quantum dots), LPSiNPs self-destruct in a mouse model into renally cleared components in a relatively short period of time with no evidence of toxicity. As a preliminary in vivo application, we demonstrate tumour imaging using dextran-coated LPSiNPs (D-LPSiNPs). These results demonstrate a new type of multifunctional nanostructure with a low-toxicity degradation pathway for in vivo applications.

Subfields: Biomedical Engineering, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/38afc58ac40ffbbcbeb3969e0bf59001c82f9fa9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. D. Giljohann
2. W. Chan
3. Chad A. Mirkin
4. Lihong V. Wang
5. K. Rumpf
6. P. Granitzer
7. Paul K. Chu
8. Vasilis Ntziachristos

In Materials Chemistry

1. Guohua Liu
2. W. Chan
3. John L. Rubinstein
4. Chad A. Mirkin
5. Kaiying Wang
6. D. Giljohann
7. K. Rumpf
8. Nils Hoivik

Citations in the corpus

• Physicochemical Properties of Nanomaterials: Implication in Associated Toxic Manifestations (2014, neutral): “[76] observed that luminescent porous silicon nanoparticles did not show any toxicity in animal models.”
• Drivers of biodiagnostic development (2009, background): “Efforts in this area are under way with silicon quantum dot”
• Porous Silicon—A Versatile Host Material (2010, methodology): “Luminescent porous silicon, exploiting the light emitting properties, has been utilized to image cells in vitro and organs in vivo [55].”
• Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy (2016, background): “…with a size range between 20 and 200 nm circumvent rapid renal filtration enabling passive accumulation in tumours at high concentrations for a longer time than organic molecules via the enhanced permeability and retention (EPR) effect that can hardly be achieved by other molecular agents 16–19 .”