New optimization method for conformational energy calculations on polypeptides: Conformational space annealing

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De novo protein structure prediction by dynamic fragment assembly and conformational space annealing (2011, background): “CSA15,40–43 is a global optimization algorithm which can be viewed as a generalized genetic algorithm.”
Improvements to Robotics-Inspired Conformational Sampling in Rosetta (2013, background): “Further, conformational space annealing, the exchange of low-scoring sub-segments between different models, is an established technique in protein modeling [41,42] that efficiently exploits information from multiple parallel simulations to identify good conformations.”
Numerical Methods for Electronic Structure Calculations of Materials (2010, unknown): “For example, local minima can be used as starting points for global minimization algorithms [8, 9, 30, 101, 112, 114, 150, 151, 171, 170, 201].”
Protein structure modeling for CASP10 by multiple layers of global optimization (2014, methodology): “…these energy functions, we utilized conformational space annealing (CSA), a powerful global optimization and efficient conformational search method.8 In addition, we developed new quality assessment methods based on random-forest machine learning algorithm to properly rank protein models at the…”