Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections.

By J. Brenchley, M. Paiardini, K. Knox, A. Asher, B. Cervasi, Tedi E. Asher, P. Scheinberg, D. Price, C. Hage, L. Kholi and 6 more. Blood, 2008

688 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Emerging Concepts in the Immunopathogenesis of AIDS (2009, background): “Investigators have recently reported a preferential loss from the GI tract of a subset of T cells that are defined by their secretion of the cytokine IL-17 (47, 48).”
Systemic effects of inflammation on health during chronic HIV infection. (2013, background): “for both antimicrobial immunity and epithelial integrity at mucosal surfaces, exacerbates and perpetuates this damage (Brenchley et al., 2008; Favre et al., 2010).”
HIV and Tuberculosis: a Deadly Human Syndemic (2011, background): “During the early stages of HIV infection, the CD4 T cell population in the intestinal lamina propria is depleted preferentially and markedly; a large fraction of the cells lost in this initial phase of infection are CD4 Th17 effector memory cells (31).”
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. (2010, background): “For example, there is significant loss of Th17 cells in the blood and mucosa of HIV-infected patients (48).”
The immune response during acute HIV-1 infection: clues for vaccine development (2009, background): “The virus then replicates rapidly and spreads throughout the body to other lymphoid tissues, particularly gut-associated lymphoid tissue (GALT), where activated CD4 + CCR5 + memory T cells are present in high number”