The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens
By E. Duchaud, C. Rusniok, L. Frangeul, C. Buchrieser, A. Givaudan, S. Taourit, S. Bocs, C. Boursaux-Eude, Michael Chandler, J. Charles and 16 more. Nature Biotechnology, 2003
611 citations recorded by the source corpus.
Photorhabdus luminescens is a symbiont of nematodes and a broad-spectrum insect pathogen. The complete genome sequence of strain TT01 is 5,688,987 base pairs (bp) long and contains 4,839 predicted protein-coding genes. Strikingly, it encodes a large number of adhesins, toxins, hemolysins, proteases and lipases, and contains a wide array of antibiotic synthesizing genes. These proteins are likely to play a role in the elimination of competitors, host colonization, invasion and bioconversion of the insect cadaver, making P. luminescens a promising model for the study of symbiosis and host-pathogen interactions. Comparison with the genomes of related bacteria reveals the acquisition of virulence factors by extensive horizontal transfer and provides clues about the evolution of an insect pathogen. Moreover, newly identified insecticidal proteins may be effective alternatives for the control of insect pests.
Subfields: Insect Science, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/eaf00ae1a734078c9abe4ceda2ddfa6809e79839
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Insect Science
In Molecular Biology
Citations in the corpus
- Cloning Serratia entomophila Antifeeding Genes—a Putative Defective Prophage Active against the Grass Grub Costelytra zealandica (2004, background): “laumondii TTO1 ( 12 ) (Table 3 and Fig. 6). Similarity was also scored to two remnant prophages in the “necrotizing factor-like pnf” gene cluster, part of a putative pathogencity island identified by Waterfield et al. (50) in the P. luminescens strain W14.”
- Theoretical and practical advances in genome halving (2004, neutral): “We hope this simplicity increases the likelihood of adoption by experimental biologists”
- The Photorhabdus asymbiotica virulence cassettes deliver protein effectors directly into target eukaryotic cells (2019, methodology): “laumondii TTO1 (Duchaud et al., 2003) were used in these studies as hosts for reporter plasmids.”
- Insect pathogens as biological control agents: Back to the future. (2015, background): “Of 1759 particular note, the entire genomes of entomopathogenic nematodes and their symbionts have 1760 been sequenced (e.g., Duchaud et al., 2003; Bai and Grewal, 2007; Ciche, 2007; Bai et al., 2009, 1761 JIP-15-82 78 2013; Schwartz et al., 2011; Bai et al., 2013).”
- Genomic islands in pathogenic and environmental microorganisms (2004, background): “tomato , Fibrobacter succinogenes and Treponema denticola — several of which are insect-associate”
- Photorhabdus Virulence Cassettes Confer Injectable Insecticidal Activity against the Wax Moth (2006, background): “Given the requirement that Photorhabdus bacteria should kill the insect host into which they are released by their nematode vector and the numerous predicted toxins encoded in the Photorhabdus luminescens TT01 genome (7), it seems likely that other classes of insecticidal toxin remain to be discover”