Photorhabdus Virulence Cassettes Confer Injectable Insecticidal Activity against the Wax Moth

By Guowei Yang, Andrea J. Dowling, U. Gerike, R. ffrench-Constant, N. Waterfield. 2006

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N-terminal signal peptides facilitate the engineering of PVC complex as a potent protein delivery system (2022, unknown): “Because the PVC has a simplified phage tail–like architecture with capacious inner lumen and can be released outside bacterial cells for puncturing reaction ( 15 ), it would be an ideal model for manipulation as an in vitro protein delivery system.”
Contractile injection systems of bacteriophages and related systems (2018, background): “These T6SS assemblies are related to the Photorhabdus Virulence Cassettes (PVCs) (Yang et al., 2006) and Afps of Serratia (Hurst et al., 2007).”
A Phage Tail-Derived Element with Wide Distribution among Both Prokaryotic Domains: A Comparative Genomic and Phylogenetic Study (2014, background): “Afp/PVC were initially grouped with R-type pyocins due to their closer genetic similarity; however, functional studies revealed that they confer toxicity toward insect hemocytes by inducing actin condensation (Yang et al. 2006).”
Three-dimensional Structure of the Toxin-delivery Particle Antifeeding Prophage of Serratia entomophila * (2013, background): “Similar particles with toxin-delivery functions are encoded by the Photorhabdus virulence cassettes (4, 7), which in turn resemble several R-type pyocins (8, 9).”