Genomic islands in pathogenic and environmental microorganisms

By U. Dobrindt, B. Hochhut, U. Hentschel, J. Hacker. Nature Reviews Microbiology, 2004

1,146 citations recorded by the source corpus.

Subfields: Ecology, Endocrinology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/6110e6c809f482005bbc5e9e6ae3441f91af435f

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Citations in the corpus

Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: a review. (2013, background): “Mainly, there are three types of such retrospective evidences as already discussed by Top and Springael (2003) in another context: (i) the association of the acquired ARG with mobile genetic elements such as plasmids, phages, transposons (Partridge, 2011), (ii) the loss of synteny between the insert”
Bacterial insertion sequences: their genomic impact and diversity (2014, background): “integrative conjugative elements, ICEs, originally called conjugative transposons, and other types of genomic island) (Burrus & Waldor, 2004) (Dobrindt et al., 2004; Guerillot et al., 2013).”
Comparative Genomics of Multidrug Resistance in Acinetobacter baumannii (2006, background): “Additional ORFs encoding a putative aminoglycoside adenylyltransferase and a tetracycline efflux pump tetA were also found in both A. baumannii strains.”
Carbon catabolite repression in bacteria: many ways to make the most out of nutrients (2008, background): “The SirA response regulator, in turn, controls expression of a type III secretion system that is encoded on Salmonella pathogenicity island 1 (SPI1”
Survival of Escherichia coli in the environment: fundamental and public health aspects (2011, background): “coli that define the different behavioural types is clearly an underpinning factor (Dobrindt et al., 2004; Touchon et al., 2009).”
IslandViewer 4: expanded prediction of genomic islands for larger-scale datasets (2017, positive): “They are a major driver of genome evolution and are of particular interest since they often provide adaptive traits that enhance the fitness of bacteria and archaea within a niche (1,2).”
Single-Cell Genomics Reveals Hundreds of Coexisting Subpopulations in Wild Prochlorococcus (2014, background): “microbial ‘species’ with very different ecologies (5-10, 25), suggesting that differentiated genomic backbones may be a feature of diverse types of microbial populations.”
Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion (2008, background): “ated genes, termed pathogenicity islands (PAI), are important steps for the rapid evolution of pathogenic bacteria from nonpathogenic progenitors (57, 266).”
The Hologenome Concept: Human, Animal and Plant Microbiota (2014, background): “…of bacterial genomes has revealed that blocks of DNA with properties similar to PAI are also present in most nonpathogenic bacteria (Dhillon et al. 2013), where they are referred to as fitness islands (Dobrindt et al. 2004), or in the case of symbionts as symbiosis islands (MacLean et al. 2007).”
Organised Genome Dynamics in the Escherichia coli Species Results in Highly Diverse Adaptive Paths (2009, background): “The Role of Genome Repertoire Dynamics in the Commensalism/Pathogenicity Duality Gene acquisition and loss have important roles in transitions between commensalism and pathogenicity [51,52].”
The rhizosphere as a reservoir for opportunistic human pathogenic bacteria. (2005, background): “Each of the factors involved has been referred to as virulence factor or pathogenicity factor (Dobrindt et al., 2004).”
Horizontal gene transfer, genome innovation and evolution (2005, background): “Such sets of genes encode functions conferring traits that allow the colonization of new ecological niche”
IslandViewer: an integrated interface for computational identification and visualization of genomic islands (2009, background): “…that contain multiple genes of probable horizontal origin, termed genomic islands (GIs), are of signiﬁcant medical interest because they disproportionately contain genes involved in virulence, antibiotic resistance or other important adaptations (Dobrindt et al ., 2004; Hacker and Kaper, 2000).”
Cyanobacterial peptides - nature's own combinatorial biosynthesis. (2006, background): “Horizontal gene transfer is well known within the frame of pathogenicity islands that often contain biosynthetic clusters (Dobrindt et al., 2004; Hochhut et al., 2005).”
Gene flow, mobile genetic elements and the recruitment of antibiotic resistance genes into Gram-negative pathogens. (2011, background): “Several important Gram-negative pathogens are known to have quite variable genomes when different strains are compared and these variable regions, genomic islands, can include concentrations of resistance genes (Dobrindt et al., 2004; Hall, 2010).”
Genomic islands: tools of bacterial horizontal gene transfer and evolution (2008, background): “As many GEIs have only been put forward on the basis of data from sequencing projects, and not on experimental evidence of their mode of action, many elements may actually be in an evolutionary state of regression, as has been suggested earlier by Dobrindt et al. (2004).”