The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans.

By Danielson Pb. 2002

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Gut microorganisms, mammalian metabolism and personalized health care (2005, background): “It could be argued that the diversity of the mammalian (and indeed other vertebrate) cytochrome P450 enzyme family, as well as other parts of the xenobiotic detoxification system, reflects evolutionary exposure to dietary toxins, mainly plant secondary metabolite”
Regulation of reactive oxygen species generation in cell signaling (2011, background): “CYP enzymes have been identified in all branches of life (Danielson, 2002).”
Pharmacokinetics and dosage adjustment in patients with renal dysfunction (2008, background): “Drug-metabolizing enzymes are found in most tissues of the body but the highest levels are located in the intestinal epithelial cells and in the liver [2, 3].”
Decoding cell death signals in liver inflammation. (2013, background): “586 Journal of Hepatology 201 enzymes of the cytochrome P450 family [51].”