Nicastrin Is Required for γ-Secretase Cleavage of the Drosophila Notch Receptor

By Yue Hu, Y. Ye, M. Fortini. 2002

165 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/eae0fa13b3b97f914eccc74b96e052c34c0aa8d9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Yue Hu
2. M. Fortini

In Molecular Biology

1. M. Fortini
2. Yue Hu
3. Christian Haass

Citations in the corpus

• Different cofactor activities in γ-secretase assembly (2003, methodology): “In the second, the nct gene of the four-component plasmid was altered by introducing the Nct 304–333 mutation that renders Nct nonfunctional in Drosophila cells (Hu et al., 2002).”
• Presenilins mediate a dual intramembranous γ‐secretase cleavage of Notch‐1 (2002, background): “…components is nicastrin (Yu et al., 2000), which is required for PS expression (Edbauer et al., 2002; Hu et al., 2002; LopezSchier and St Johnston, 2002), g-secretase activity (Edbauer et al., 2002) and Notch S3 cleavage (Chung and Struhl, 2001; Hu et al., 2002; Lopez-Schier and St Johnston, 2002).”