Presenilins mediate a dual intramembranous γ‐secretase cleavage of Notch‐1

By M. Okochi, H. Steiner, Akio Fukumori, H. Tanii, T. Tomita, Toshihisa Tanaka, T. Iwatsubo, T. Kudo, M. Takeda, Christian Haass. 2002

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The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism (2009, background): “…initial cleavage at site 3 releases NICD, whereas the last cleavage at site 4 releases the Nß peptide (named after the Aß peptide, which is released from another γ-secretase substrate, amyloid precursor protein, which is associated with Alzheimer’s disease; Okochi et al., 2002) (Figures 1 and 2A).”
Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies (2016, background): “Presenilins are also implicated in the processing of notch [104,105], an important developmental protein (mice that have PS1 knocked out die early in development from developmental abnormalities similar to those found when notch is disrupted, [106]).”