Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

By Levi A. Garraway, H. Widlund, Mark A. Rubin, Gad Getz, Aaron J. Berger, Sridhar Ramaswamy, Rameen Beroukhim, D. Milner, S. Granter, Jinyan Du and 8 more. Nature, 2005

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Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ea67bffc6d3b8291300df476a4cfba3105ea55c5

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Citations in the corpus

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq (2016, neutral): “The transcriptional programs associated with principal components PC4 and PC5 were highly correlated with expression of MITF (microphthalmia-associated transcription factor), which encodes the master melanocyte transcriptional regulator and a melanoma lineage-survival oncogene (26).”
Integrative genomic approaches identify IKBKE as a breast cancer oncogene. (2007, methodology): “Indeed, recent applications of these technologies led to the identification of MITF, c-IAP1, and YAP as human oncogenes (Garraway et al., 2005; Zender et al., 2006).”
Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. (2006, background): “…would be affected either by genetic mutations, such as activating mutations in -catenin (Rubinfeld et al. 1997) or amplification of the MITF gene (Garraway et al. 2005), or by autocrine, paracrine or other external signals arising from the tumor microenvironment through interactions with other…”
In vivo switching of human melanoma cells between proliferative and invasive states. (2008, background): “Garraway and coworkers ( 15 ) have shown MITF gene amplification in a fraction of melanomas and showits correlation w ith a poorer prognosis.”
A Landscape of Driver Mutations in Melanoma (2012, background): “Cell 150, 251–263, July 20, 2012 ª2012 Elsevier Inc. 261 Cell Culture Human primary melanocytes (pMEL/hTERT/CDK4(R24C)/p53DD) expressing either BRAF(V600E) (pMEL-BRAF) or NRAS(G12D) (pMEL-NRAS) have been previously described (Garraway et al., 2005; Scott et al., 2011).”