Thrombin signalling and protease-activated receptors

By S. Coughlin. Nature, 2000

2,568 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Hematology

View Paper: https://www.semanticscholar.org/paper/ea514bb29a83aa5fab699fe1163fc79e3f0bcc24

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. U. Hanisch
2. Asrar B. Malik
3. Xi Wang
4. R. Khalil
5. S. Verma
6. M. Levi
7. D. Mehta
8. Carine Michiels

In Genetics

1. U. Hanisch
2. Asrar B. Malik
3. H. Versteeg
4. Xi Wang
5. Pieter H. Reitsma
6. R. Khalil
7. S. Verma
8. J. Heemskerk

In Hematology

1. U. Hanisch
2. Asrar B. Malik
3. H. Versteeg
4. Xi Wang
5. Pieter H. Reitsma
6. R. Khalil
7. S. Verma
8. J. Heemskerk

Citations in the corpus

• Proteinase-activated receptors. (2001, neutral): “Such is the rapidly expansive nature of the field; the reader is directed to a number of excellent recent shorter reviews that will complement this current work (Grand et al., 1996; Hollenberg, 1996; Dery et al., 1998; Cocks and Moffatt, 2000; Coughlin, 2000).”
• Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome* (2006, background): “Although altered coagulation and fibrinolysis, both systemically and in the alveolar compartment, were first described in patients with ARDS some years ago (5–7), the relationship of procoagulant to proinflammatory events in causing organ injury has been better appreciated recently (8, 9).”
• Inflammation, endothelium, and coagulation in sepsis (2008, background): “In linking coagulation to inflammation, PARs seem to play a pivotal role [103, 104].”
• Mechanisms of fibrosis: therapeutic translation for fibrotic disease (2012, neutral): “In addition to its role in the coagulation cascade, thrombin can directly promote fibrosis by inducing production of chemokine (C-C motif) ligand 2 (CCL2) and by signaling through protease-activated receptors expressed on liver fibroblasts (hepatic stellate cells) 12 .”
• Protease-activated receptors: contribution to physiology and disease. (2004, background): “The contributions of proteases and their receptors to regulation the cardiovascular system have been recently reviewed (50, 68, 226, 240).”
• Signaling mechanisms regulating endothelial permeability. (2006, background): “In addition, thrombin has been shown to regulate cellular processes such as hemostasis, mitogenesis, and smooth muscle contraction (190).”
• Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease. (2018, background): “PAR-1 is expressed on a number of different types of cells including endothelial cells, platelets, leukocytes and smooth muscle cells (McNamara et al., 1993; Coughlin, 2000), and is an important target for MMP-1 and MMP-13 (Coughlin, 2001; Macfarlane et al., 2001; Coughlin, 2005).”
• Blood-brain barrier pathophysiology in traumatic brain injury (2011, background): “Three PARs, PAR1, PAR-3, and PAR-4, are activated by thrombin, whereas PAR2 is activated by trypsin and tryptase, as well as by coagulation Factors VIIa and Xa [26].”
• New fundamentals in hemostasis. (2013, background): “PARs are seventransmembrane domain G protein-coupled receptors that are activated by proteolytic removal of their NH2-terminal exodomains (59).”