Connections and Regulation of the Human Estrogen Receptor

By D. McDonnell, J. Norris. Science, 2002

614 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

G-protein-coupled receptors and cancer (2007, background): “These steroid hormones activate their cognate androgen and oestrogen receptors ( AR and ER ), which are transcription factors of the nuclear hormone receptor famil”
Biological determinants of endocrine resistance in breast cancer (2009, background): “ERα is responsible for many of the effects of oestrogen on normal and cancerous breast tissue, through ligand-activated transcriptional regulation (genomic actions) and by acting as a component of membrane and cytoplasmic signalling cascades (non-genomic actions”
X-Tile (2004, background): “In contrast, the expression of ER is highly complex and governed by a number of regulatory elements (14).”
The X-files in immunity: sex-based differences predispose immune responses (2008, background): “In addition, oestrogen–ERα or oestrogen–ERβ complexes might regulate the transcriptional activity of genes that do not have an ER-responsive element by recruiting co-regulatory proteins that can activate or repress transcriptio”