Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

By Hao Xu, Jieling Yang, Wenqing Gao, Lin Li, Peng Li, Li Zhang, Yi-Nan Gong, Xiaolan Peng, J. Xi, She Chen and 2 more. Nature, 2014

771 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/ea05173fb963a23f4dec5a536fea390832a40ab3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. T. Kanneganti
2. M. Lamkanfi
3. Edward A. Miao
4. S. Man
5. G. van Loo

In Molecular Biology

1. T. Kanneganti
2. S. Man
3. M. Lamkanfi
4. Edward A. Miao
5. Ine Jorgensen
6. G. van Loo
7. R. Malireddi
8. S. Kesavardhana

In Physiology

1. M. Lamkanfi

Citations in the corpus

• Role of pyroptosis in inflammation and cancer (2022, background): “To date, it has been found that the PYRIN inflammasome is activated by pathogenic toxins, such as cytotoxic TcdB [62, 63] (Fig.”
• Inflammasomes in neuroinflammatory and neurodegenerative diseases (2019, background): “…of type III secretion systems (T3SS) of bacterial pathogens (Franchi et al, 2006; Miao et al, 2006, 2010); AIM2 physically binds cytosolic doublestranded DNA (dsDNA) (Hornung et al, 2009); and pyrin indirectly responds to toxins that covalently inactivate the small GTPase RhoA (Xu et al, 2014).”
• Regulation of inflammasome activation (2015, background): “Xu H, et al. Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome.”