Otto Warburg's contributions to current concepts of cancer metabolism

By W. Koppenol, P. L. Bounds, C. V. Dang. Nature Reviews. Cancer, 2011

1,461 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e9dc3a43c91270655499f352cb3525ba70f5e9c7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

Metabolic reprogramming: the emerging concept and associated therapeutic strategies (2015, background): “It remains unclear why cancer cells largely depend on this “inefficient” metabolic pathway, even when enough oxygen is available [27, 28].”
Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation. (2014, background): “The upregulation of glycolysis in normoxic cancer cells is known as the Warburg effect (Koppenol et al., 2011), a phenomenon that is characterized by an increased glycolytic flux with lactate production from pyruvate even in the presence of abundant O2 (Vander Heiden et al., 2009).”
The Science and Translation of Lactate Shuttle Theory. (2018, background): “The high glucose uptake/lactate release phenotype remains a hallmark of cancer (Hanahan and Weinberg, 2000; Koppenol et al., 2011), but today there is no consensus on the meaning of the observations.”
Revisiting the Warburg effect: historical dogma versus current understanding (2020, background): “…metabolism has also been described in early mammalian embryos to support rapid cell proliferation and growth, with similarities and differences in the underlying regulatory mechanisms (e.g. Redel et al. 2012; Krisher & Prather, 2012; Smith & Sturmey, 2013; Miyazawa & Aulehla, 2018; Manzo, 2019).”
The Warburg Effect: How Does it Benefit Cancer Cells? (2016, background): “Concluding Remarks Extensive research on the Warburg Effect and its functions in cancer cells has advanced our understanding of its causes and requirements for tumor cell proliferation [29,52].”
Metabolic Regulation of T Lymphocytes (2013, background): “In a seminal finding nearly a century ago, Otto Warburg (1) first observed that rather than relying on mitochondrial oxidative pathways for maximal energy generation, cancer cells use the less efficient process of glycolysis, producing lactic acid even in the presence of sufficient oxygen (2).”
Drug resistance and combating drug resistance in cancer (2019, background): “These cancer cells are “addicted” to glucose and are more sensitive to glucose concentration changes than normal cells, dying significantly faster than normal cells under glucose deprivation([99,166,167,205]).”
Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer (2014, background): “Tumor cells use a variety of oncogenically- and environmentally driven metabolic pathways to meet the bioenergetic and biosynthetic demands of rapid and sustained growth (1, 2).”
Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma (2021, background): “Since Warburg effect (aerobic glycolysis) is one of the hallmarks of cancer [14], cancer cells tend to use ‘ferment’ glucose into lactate for energy generation even in aerobic conditions, with more lactate metabolized by glucose in a given time than normal cells [15].”
Loss of FBP1 by Snail-mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer (2013, neutral): “Otto Warburg noticed that some tumor cells preferentially metabolized glucose to lactate in the presence of ample oxygen, a process called aerobic glycolysis (Koppenol et al., 2011).”
The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism (2014, methodology): “Warburg observed that the absolute rate of mitochondrial respiration in cancer cells remains comparable to that of normal cells [4].”
Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells (2015, background): “In contrast to most normal tissues, cancer cells consume increased amounts of glucose andmetabolizemuchof this glucose to lactate even in thepresenceof ample oxygen (Koppenol et al., 2011; Warburg et al., 1924).”
Fundamentals of cancer metabolism (2016, background): “Glycolysis is a physiological response to hypoxia in normal tissues, but Otto Warburg in the 1920s observed that tumor slices and ascites cancer cells constitutively take up glucose and produce lactate regardless of oxygen availability, an observation that has been seen in many types of cancer cells”