Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment.

By Youjin Lee, S. Auh, Yugang Wang, Byron Burnette, Yang Wang, Yuru Meng, M. Beckett, Rohit Sharma, R. Chin, T. Tu and 2 more. Blood, 2009

1,292 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/e95d6232e917bcf8fbd2e25181e253d983d09a22

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In Oncology

Citations in the corpus

Radiation and Dual Checkpoint Blockade Activates Non-Redundant Immune Mechanisms in Cancer (2015, positive): “For melanoma and breast cancer models, we used the optimal dose and fraction of radiation as previously reported 23,24 .”
STING-dependent Cytosolic DNA Sensing Promotes Radiation-induced Type I interferon-dependent Antitumor Immunity in Immunogenic Tumors (2014, background): “Radiation has been demonstrated to induce adaptive immune responses to support tumor regression (Apetoh et al., 2007; Lee et al., 2009).”
Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. (2014, positive): “org Volume 124 Number 2 February 2014 Altogether, these results demonstrate that CD8+ T cells are necessary for the therapeutic effects of IR plus anti–PD-L1 therapy and are in agreement with our previous observations using IR as a single modality (2, 3, 31).”
Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11 (2019, methodology): “CD8+ T Cells Promote Radiotherapy-Induced Ferroptosis via IFNγ CD8+ T cells are required for efficacy of ablative doses of radiotherapy in vivo (21, 22).”
Combining radiotherapy and cancer immunotherapy: a paradigm shift. (2013, background): “It is also unclear whether standard radiation doses and fractionations for a given tumor type should be modified if radiation is to be used to convert the tumor into an in situ vaccine (119,120).”
The Efficacy of Radiotherapy Relies Upon Induction of Type I Interferon-Dependent Innate and Adaptive Immunity (2011, methodology): “Mice received local irradiation as described previously (3).”
Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Anti-Tumor Immune Responses via Cross-Presentation of Tumor Antigen (2014, background): “Specifically, depleting CD8 T cells reduced the antitumor effect of XRT and decreased survival of mice with melanoma tumors (14, 15).”