Role of cell cycle on the cellular uptake and dilution of nanoparticles in a cell population.
By Jong Ah Kim, Christoffer Åberg, Anna Salvati, Kenneth A. Dawson. Nature Nanotechnology, 2011
624 citations recorded by the source corpus.
Nanoparticles are considered a primary vehicle for targeted therapies because they can pass biological barriers and enter and distribute within cells by energy-dependent pathways. So far, most studies have shown that nanoparticle properties, such as size and surface, can influence how cells internalize nanoparticles. Here, we show that uptake of nanoparticles by cells is also influenced by their cell cycle phase. Although cells in different phases of the cell cycle were found to internalize nanoparticles at similar rates, after 24 h the concentration of nanoparticles in the cells could be ranked according to the different phases: G2/M > S > G0/G1. Nanoparticles that are internalized by cells are not exported from cells but are split between daughter cells when the parent cell divides. Our results suggest that future studies on nanoparticle uptake should consider the cell cycle, because, in a cell population, the dose of internalized nanoparticles in each cell varies as the cell advances through the cell cycle.
Subfields: Biomedical Engineering, Materials Chemistry, Pollution
View Paper: https://www.semanticscholar.org/paper/0cdb8cbb1d1b235fe7e5fba115e895aa54a71cf1
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Materials Chemistry
Citations in the corpus
- Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo (2012, neutral): “of nanoparticles depends on many factors, including the size(27,29) or shape(30) 32 of the nanoparticles, surface charge,(5,33,34) sedimentation and diffusion velocity effects of large and dense particles,(35) composition of the protein corona on the nanoparticles,(36) competition between receptors ”
- Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle (2013, background): “sures change in fluorescence spectra due to NP-protein interaction [65]”
- Effects of the presence or absence of a protein corona on silica nanoparticle uptake and impact on cells. (2012, background): “Their characterization in the same media is reported elsewhere.(1,40,42) Cell Culture.”