TAL Effectors: Customizable Proteins for DNA Targeting

By Adam J. Bogdanove, Daniel F. Voytas. Science, 2011

954 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/e926f4510405ac6671524d548e0222f8510fc407

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Citations in the corpus

A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions (2012, background): “TAL effector repeats bearing different RVDs have been described for specific binding to each of the four possible DNA nucleotides, and these repeats can be simply joined together to create arrays capable of binding to extended target DNA sequences (Bogdanove and Voytas, 2011).”
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering (2013, neutral): “Alternative methods have been developed to accelerate the process of genome modification by directly injecting DNA or mRNA of site-specific nucleases into the one-cell embryo to generate DNA double-strand break (DSB) at a specified locus in various species (Bogdanove and Voytas, 2011; Carroll et al.”
TAL Effector-Nucleotide Targeter (TALE-NT) 2.0: tools for TAL effector design and target prediction (2012, methodology): “Increasingly, therefore, TAL effectors and TAL effector-based fusion proteins have been adopted as tools for DNA targeting applications (6).”
Salt resistant crop plants. (2014, background): “Designer nucleasebased approaches to alter genetic composition, such as Transcription Activator-Like Effector Nucleases (TALEN) [82–85], are reported to increase the mutagenesis efficiency of endogenous targets by specifying their binding sites with single nucleotide precision [85].”
RNA-programmed genome editing in human cells (2013, background): “Zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) have proved effective for such genomic manipulation but their use has been limited by the need to engineer a specific protein for each dsDNA target site and by off-target activity (Urnov et al., 2010; Bogdanove”
Genome Editing of Plants (2017, background): “TALENs are similar to ZFNs in that they have a DNA binding domain distinct from the FokI endonuclease domain (Christian et al., 2010; Bogdanove and Voytas, 2011).”
A CRISPR/Cas9 Toolbox for Multiplexed Plant Genome Editing and Transcriptional Regulation1[OPEN] (2015, background): “Compared to ZFNs, TALENs possess a broader targeting range and 109 are less difficult to engineer (Bogdanove and Voytas, 2011; Doyle et al., 2012).”
Efficient TALEN-mediated gene knockout in livestock (2012, background): “Transcription activator-like effector nucleases (TALENs), like ZFNs, consist of assembled DNA-binding motifs coupled to the FokI nuclease (6, 14).”
The CRISPR/Cas9 system produces specific and homozygous targeted gene editing in rice in one generation. (2014, background): “Later advances in the engineering of site-specific nucleases, such as zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs), have allowed more reliable targeted plant gene editing (Bogdanove and Voytas, 2011; Carroll, 2011).”