Viral metagenomics

By Robert A. Edwards, Forest Rohwer. Nature Reviews Microbiology, 2005

870 citations recorded by the source corpus.

Subfields: Ecology, Infectious Diseases, Plant Science

View Paper: https://www.semanticscholar.org/paper/e9250b92f607421eacb754e391fab347ec3ce1c1

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Citations in the corpus

Computational approaches to predict bacteriophage–host relationships (2015, background): “Metagenomics, the untargeted shotgun sequencing of DNA or RNA isolated directly from the environment, is increasingly identifying viral sequences in every imaginable ecosystem (Edwards and Rohwer 2005; Mokili, Rohwer and Dutilh 2012).”
The ancient Virus World and evolution of cells (2006, background): “Recent environmental studies have shown that viruses, primarily, bacteriophages, are "most abundant biological entities on the planet" [2], with the total number of virus particles exceeding the number of cells by at least an order of magnitude [3,4].”
Horizontal Gene Exchange in Environmental Microbiota (2011, background): “In fact, the metagenomic approach is the only way to characterize the viral diversity because there is no single gene common to all phages to serve as a phylogenetic marker (Edwards and Rohwer, 2005).”
ViPTree: the viral proteomic tree server (2017, background): “Viruses are the most abundant biological entities and a reservoir of the greatest genetic diversity on Earth (Edwards and Rohwer, 2005; Suttle, 2005).”
The Marine Viromes of Four Oceanic Regions (2006, neutral): “60% of the sequences were unknowns [33].”
The Logic of Chance: The Nature and Origin of Biological Evolution (2011, background): “Recently, the study of viromes (the totality of viruses detectable in a given habitat) has become a vibrant research field (Edwards and Rohwer, 2005; Kristensen, et al., 2010).”
The Sorcerer II Global Ocean Sampling Expedition: Expanding the Universe of Protein Families (2007, background): “Viral metagenomics projects have reported an equally high fraction of novel ORFs [53], and a recent marine metagenomics project estimated that up to 21% of photic zone sequences could be of viral origin [51].”
New perspectives in benthic deep-sea microbial ecology (2015, background): “…viruses in marine ecosys - tems is complex due to the difficulty in identifying conserved genes in the viral genomes ( such as the ribosomal genes of bacte - ria , archaea , and eukaryotes ) , and because most of the viral hosts cannot be cultivated ( Edwards and Rohwer , 2005 ; Schoenfeld et al .”
The human gut virome: inter-individual variation and dynamic response to diet. (2011, background): “Bacteriophages are the most abundant biological entities on Earth, with an estimated population of ;10(31) total particles (Weinbauer 2004; Suttle 2005), but their roles in human health are only beginning to be studied (Edwards and Rohwer 2005; Breitbart et al. 2008; Reyes et al. 2010).”
The Pacific Ocean Virome (POV): A Marine Viral Metagenomic Dataset and Associated Protein Clusters for Quantitative Viral Ecology (2013, background): “Perhaps chief among them is that ,1% of microbes in an environment can be routinely grown in the laboratory [11,12].”