Two populations of node monocilia initiate left-right asymmetry in the mouse.

By J. Mcgrath, S. Somlo, S. Makova, X. Tian, M. Brueckner. Cell, 2003

825 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/e8f843113f86764e643b2258a7715e3842130f08

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Citations in the corpus

Mechanical control of tissue and organ development (2010, background): “The flow also causes the asymmetric deformation of the non-motile cilia at the periphery of the node, which activates asymmetric calcium influx through mechanosensitive polycystin-2 ion channels (McGrath et al., 2003).”
The TRP Superfamily of Cation Channels (2005, background): “In addition, TRPP2-deficient mice display a laterality phenotype (201, 202), which is described in more detail below.”
TRP Channels (2012, neutral): “This process is regulated by a nodal ciliary mechanism, resulting in an asymmetric calcium signal (265).”
Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis (2005, background): “…(Nonaka et al., 1998; Okada et al., 1999); or (2) fluid flow per se is sufficient to provide a mechanical signal that breaks left-right symmetry, possibly by stimulating non-motile, mechanosensory cilia and subsequent intracellular calcium signaling (McGrath et al., 2003; Tabin and Vogan, 2003).”
Forces in tissue morphogenesis and patterning. (2013, neutral): “Most prominently, fluid flow within the organ of laterality has been shown to control embryo patterning along its left-right (LR) axis in various species (Nonaka et al., 1998; McGrath et al., 2003; Tanaka et al., 2005).”
Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut (2005, background): “At the end of gastrulation, DFCs migrate deep into the embryo and organize to form KV (Cooper and D’Amico, 1996; D’Amico and Cooper, 1997; Melby et al., 1996).”
The graded response to Sonic Hedgehog depends on cilia architecture. (2007, result): “…and hnn mutant nodal cilia (Figures 4E and 4F); this finding would be consistent with the observation that there are motile and immotile cilia present in the node (McGrath et al., 2003) as well as recent data showing the presence of a central pair in rabbit nodal cilia (Feistel and Blum, 2006).”