Metastasis: Metastasis to bone: causes, consequences and therapeutic opportunities

By G. Mundy. Nature Reviews. Cancer, 2002

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A multigenic program mediating breast cancer metastasis to bone. (2003, background): “Osteoclasts the tissue from which it was isolated are also indicated. are direct mediators of bone resorption in osteolytic bone me- tastases (Boyce et al., 1999; Mundy, 2002).”
Axis of evil: molecular mechanisms of cancer metastasis (2003, background): “Type I collagen, which comprises 90% of the bone matrix, has been shown to stimulate the motility of tumor cells (Mundy, 2002).”
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. (2003, background): “1 on tumorserved bone metastasis and subsequent osteoblastic/osteoinitiation has been reported (Kim et al., 2002).clastic lesions (Bubendorf et al., 2000; Cher, 2001; Harada et PSCA is another molecule that we identified by microarrayal., 1992; Mundy, 2002).”
Tumor-associated macrophages: from mechanisms to therapy (2014, background): “Because this process is dependent on a different cell type to classical macrophages it will not be reviewed further here, but readers are referred to recent reviews that discuss the process and therapeutic opportunities (Camacho and Pienta, 2014; Esposito and Kang, 2014; Mundy, 2002).”