Molecular Epidemiology of Human Coronavirus OC43 Reveals Evolution of Different Genotypes over Time and Recent Emergence of a Novel Genotype due to Natural Recombination

By S. Lau, Paul Lee, Alan K. L. Tsang, Cyril C Y Yip, H. Tse, R. Lee, L. So, Y. Lau, Kwok-Hung Chan, Patrick C. Y. Woo and 1 more. 2011

257 citations recorded by the source corpus.

Subfields: Animal Science and Zoology, Infectious Diseases

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Citations in the corpus

Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e (2020, unknown): “Inside these virions is a positive-sense RNA genome of roughly 30 kB ( Li, 2016 ).”
Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses (2016, background): “Genotype A is typified by the prototype VR759 strain that was isolated in 1967 [75].”
The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control (2020, background): “Recombination is another mechanism of evolution in coronaviruses [50].”
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus (2020, unknown): “Additionally, recombination can add a confounding factor to phylogenetic reconstructions, and recom bination is known to play a role in natural coronavirus evolution (Graham and Baric, 2010; Lau et al., 2011; Li et al., 2020; Oong et al., 2017; Rehman et al., 2020), and recombinant sequence (potenti”
Molecular Evolution of Human Coronavirus Genomes (2016, unknown): “Nonetheless, two reports indicated that genotype D has become predominant in the East Asian population [58,59].”
Genetic drift of human coronavirus OC43 spike gene during adaptive evolution (2015, background): “HCoV-OC43 is the most prevalent CoV in humans and the relatively abundant number of clinical cases and corresponding epidemiological data make it a good model for HCoV adaption evolution 1, 5, 9, [15] [16] [17] .”
Hosts and Sources of Endemic Human Coronaviruses (2018, result): “Similar recombination breakpoints were also reported for SARS- and SARS-like CoV and HCoV-OC43 (Hon et al., 2008; Lau et al., 2010, 2011).”
Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus (2012, methodology): “Viral RNA was extracted from the tracheal, rectal, and cloacal swabs and nasopharyngeal aspirates using RNeasy Mini Spin column (Qiagen, Hilden, Germany) (27, 45, 47, 50).”
Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? (2019, unknown): “The HCoV-229E, -OC43, -NL63 and -HKU1 strains are endemic worldwide [31, 184, [194] [195] [196] [197] [198] [199] and exist in different genotypes [200] [201] [202] [203] [204] [205] [206] [207] .”