Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond.

By E. Tunbridge, Paul J. Harrison, Daniel R. Weinberger. Biological Psychiatry, 2006

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Intermediate phenotypes and genetic mechanisms of psychiatric disorders (2006, background): “, COMT is a crucial determinant of prefrontal dopamine flu”
New tools for studying microglia in the mouse and human CNS (2016, background): “Another highly expressed gene is Comt, the enzyme responsible for the degradation of catecholamines (dopamine, epinephrine, norepinephrine), which is targeted by inhibitors to increase the efficacy of L-DOPA treatments for Parkinson disease patients, and is strongly associated with schizophrenia (45”
Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives (2007, background): “Tunbridge et al. (2006), reviewing the literature on COMT polymorphisms, conclude that the Met allele is associated with improved executive function compared with the Val allele, but also with impaired emotional processing.”
Application of functional near-infrared spectroscopy in psychiatry (2014, background): “mine availability and prefrontal functioning (Tunbridge et al., 2006), with patients and controls being located on different positions on”