Lysosomal Glycosphingolipid Recognition by NKT Cells

By Dapeng Zhou, J. Mattner, C. Cantu, N. Schrantz, Ning Yin, Ying Gao, Y. Sagiv, K. Hudspeth, Yun-Ping Wu, T. Yamashita and 7 more. Science, 2004

1,027 citations recorded by the source corpus.

Subfields: Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/e844402796c258296c2465518abfe03e717fd24d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. M. Kronenberg

In Immunology

1. A. Varki
2. M. Kronenberg
3. D. Godfrey
4. B. Beutler
5. A. Bendelac
6. N. Xiong
7. L. Teyton
8. É. Vivier

Citations in the corpus

• Raising the NKT cell family (2010, background): “Although the glycosphingolipid iGb3 has been proposed to have this rol”
• Dendritic cells: translating innate to adaptive immunity. (2006, background): “The glycolipids can derive from endogenous [129], microbial [130, 131], and”
• Recognition of bacterial glycosphingolipids by natural killer T cells (2005, methodology): “cAMP, Dpd crosslinks, creatinine urinary values, carboxy-terminal telopeptides of type-I collagen (CTX), leptin, insulin and PTH serum levels were measured using commercial kits.”
• Biological roles of glycans (2016, background): “An alternative form of self/nonself recognition is exemplified by foreign glycolipid presentation by CD1 molecules, which are detected by restricted or invariant TCRs of NKT cells (837) (838) (839) (840) (841) (842) .”
• Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria (2006, background): “, all of the previously defined antigens that activate most i NKT cells are glycosphingolipid”
• The biology of NKT cells. (2007, background): “The presentation of diglycosylated αGalCer variants requiring processing prior to NKT cell recognition, an important tool for research (56), or of iGb4, which requires processing into iGb3 prior to recognition, is also abolished (26).”
• T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse (2011, background): “Submitted: 9 February 2011 Accepted: 15 April 2011 in lysosomes, and it was recently shown that when the catabolic enzyme -galactosidase is absent, CD1d+ cells are able to activate iNKT cells (Bendelac et al., 1995; Zhou et al., 2004; Darmoise et al., 2010).”
• Glycosylation in cellular mechanisms of health and disease. (2006, background): “Normal mammalian glycan structures can also function as self-antigens in facilitating the development of immune cell types and their responses to infection, such as in the establishment of NKT cells by endogenous glycolipid ligands for CD1d (Zhou et al., 2004).”
• The crystal structure of human CD1d with and without α-galactosylceramide (2005, background): “This search has resulted in the identification of isoglobotrihexosylceramide (iGb3) as a self ligand responsible for the in vivo development of iNKT cell”
• Targeting natural killer cells and natural killer T cells in cancer (2012, background): “In contrast to conventional T cells, which are selected by antagonist or partial ligands, it is thought that iNKT cells are selected by agonist ligand”