Recognition of bacterial glycosphingolipids by natural killer T cells

By Y. Kinjo, Douglass Wu, Gisen Kim, Guo‐wen Xing, M. Poles, D. Ho, M. Tsuji, K. Kawahara, Chi‐Huey Wong, M. Kronenberg. Nature, 2005

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Subfields: Immunology

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Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells (2010, background): “E9-Endogen); CD1d (CD1d51, kindly provided by Steven Porcelli); CD8b (GenWay); CD49d (9F10), LEAF ms IgG1, LEAF msIgG2a, Integrin B7 (FIB504) (Biolegend); MR1 (26.5) [28]; Va7.”
The biology of NKT cells. (2007, background): “NKT cell activation enhances microbial clearance by 15- to 1000-fold within the first 2–3 days of infection (23, 24).”
Identification of an IL-17–producing NK1.1neg iNKT cell population involved in airway neutrophilia (2007, neutral): “burgdorferi, which causes Lyme disease (11, 12).”
The crystal structure of human CD1d with and without α-galactosylceramide (2005, background): “, and they bind and present glycosphingolipids from α-proteobacteria such as Sphingomonas capsulata and Ehrlichia muris”
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria (2006, background): “However, it has been reported that most i NKT cells directly recognize natural α-linked glycosphingolipids from sphingomonas bacteri”
Dendritic cells: translating innate to adaptive immunity. (2006, background): “The glycolipids can derive from endogenous [129], microbial [130, 131], and”