Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.

By Sandrine Cestèle, William A. Catterall. Biochimie, 2000

709 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e79fbc3e1836ae03e88a8a0f9d43b935ccd995e6

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In Cellular and Molecular Neuroscience

In Molecular Biology

Citations in the corpus

Evidence for saxitoxins production by the cyanobacterium Aphanizomenon gracile in a French recreational water body (2010, background): “After binding to the site 1 of the sodium channels (Cestèle and Catterall, 2000), sodium transport is blocked, resulting in the inhibition of axonal depolarization, and thus leading to muscle paralysis.”
International Union of Pharmacology. XLVIII. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels (2005, background): “Transmembrane segments IS6 and IVS5 are implicated in brevetoxin binding from photoaffinity labeling studies (Cestèle and Catterall, 2000).”
Voltage-gated ion channels and gating modifier toxins. (2007, background): “Early pharmacological studies led to the conclusion that neurotoxins act at four distinct receptor sites and have primary effects on either ion permeation or voltage-dependent gating (Table 1; Catterall, 1980; Martin-Eauclaire and Couraud, 1992; Cestèle and Catterall, 2000).”
International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels (2005, background): “Transmembrane segments IS6 and IVS5 are implicated in brevetoxin binding from photoaffinity labeling studies (Cestèle and Catterall, 2000).”
Neurotoxic Alkaloids: Saxitoxin and Its Analogs (2010, neutral): “Figure adapted from [30].”
Molecular interaction of δ‐conotoxins with voltage‐gated sodium channels (2005, background): “Studies of the physical interaction between NaV channels and neurotoxins have revealed various binding sites for neurotoxins on the channel proteins (termed receptor site-1 through site-9 [1,2]), where only sites 1–5 are molecularly defined.”