Neurotoxic Alkaloids: Saxitoxin and Its Analogs
By M. Wiese, P. D’Agostino, T. Mihali, M. Moffitt, B. Neilan. Marine Drugs, 2010
698 citations recorded by the source corpus.
Saxitoxin (STX) and its 57 analogs are a broad group of natural neurotoxic alkaloids, commonly known as the paralytic shellfish toxins (PSTs). PSTs are the causative agents of paralytic shellfish poisoning (PSP) and are mostly associated with marine dinoflagellates (eukaryotes) and freshwater cyanobacteria (prokaryotes), which form extensive blooms around the world. PST producing dinoflagellates belong to the genera Alexandrium, Gymnodinium and Pyrodinium whilst production has been identified in several cyanobacterial genera including Anabaena, Cylindrospermopsis, Aphanizomenon Planktothrix and Lyngbya. STX and its analogs can be structurally classified into several classes such as non-sulfated, mono-sulfated, di-sulfated, decarbamoylated and the recently discovered hydrophobic analogs—each with varying levels of toxicity. Biotransformation of the PSTs into other PST analogs has been identified within marine invertebrates, humans and bacteria. An improved understanding of PST transformation into less toxic analogs and degradation, both chemically or enzymatically, will be important for the development of methods for the detoxification of contaminated water supplies and of shellfish destined for consumption. Some PSTs also have demonstrated pharmaceutical potential as a long-term anesthetic in the treatment of anal fissures and for chronic tension-type headache. The recent elucidation of the saxitoxin biosynthetic gene cluster in cyanobacteria and the identification of new PST analogs will present opportunities to further explore the pharmaceutical potential of these intriguing alkaloids.
Subfields: Environmental Chemistry, Organic Chemistry, Pharmacology
View Paper: https://www.semanticscholar.org/paper/9c93f0e395bf5fda1b8ff7b4b084df501346aae3
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In Environmental Chemistry
Citations in the corpus
- Biology, ecology and bloom dynamics of the toxic marine dinoflagellate Pyrodinium bahamense (2012, background): “Ammons et al. (2001) reported on the presence of PSTs in mussels from Trinidad but the source of the toxins was not identified.”
- Paralytic shellfish toxins or spirolides? The role of environmental and genetic factors in toxin production of the Alexandrium ostenfeldii complex (2013, background): “PSTs are a group of heat-stable, water-soluble alkaloids with close to 60 analogs, including saxitoxin, which is one of the most potent natural neurotoxins known (Wiese et al., 2010).”