Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver.

By G. Kullak-Ublick, M. Ismair, Bruno Stieger, L. Landmann, R. Huber, F. Pizzagalli, K. Fattinger, P. Meier, B. Hagenbuch. Gastroenterology, 2001

763 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/e72c41b92e9dd7b22a3c9d98393d183b1982a008

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. M. Roth
2. A. Obaidat
3. M. Niemi
4. B. Hagenbuch
5. Kathleen M. Giacomini
6. R. Kim
7. S. Yee
8. J. L. Boyer

In Oncology

1. M. Niemi
2. A. Kalliokoski
3. B. Hagenbuch
4. M. Roth
5. A. Obaidat
6. P. Meier
7. P. Neuvonen
8. M. Pasanen

In Spectroscopy

1. L. Benet

Citations in the corpus

• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, neutral): “OATP1B3 facilitates the uptake of different endogenous and exogenous compounds into the liver, e.g. bilirubin, cholecystokinin octapeptide (CCK-8), benzylpenicillin, bosentan, digoxin, paclitaxel and enalapril (Ismair et al. 2001; Kullak-Ublick et al. 2001; Smith et al. 2005).”
• Membrane transporters in drug development (2010, background): “However, OATP1B3 also exhibits unique transport properties in that it is able to mediate the cellular uptake of the opioid peptide deltorphin I”
• Impact of OATP transporters on pharmacokinetics (2009, background): “Endogenous substrates of OATP2B1 include dehydroepiandrosterone-3-sulfate, estrone-3-sulfate and prostaglandin E2 (Tamai et al., 2000; Kullak-Ublick et al., 2001).”
• OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies (2012, background): “OATP2B1 is also widely expressed throughout the body (Tamai et al., 2000; Kullak-Ublick et al., 2001).”
• Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation (2010, neutral): “1) (Tamai et al., 2000a; Kullak-Ublick et al., 2001; Pizzagalli et al., 2002; Grube et al., 2006a).”
• Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties (2004, background): “laevis oocytes and in transiently transfected HEK293 cells [3, 22].”
• Organic Anion Transporting Polypeptide 1B1: a Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake (2011, background): “Moreover, the contribution of other influx transporters (e.g., OATP1B3 and OATP2B1) to the hepatic uptake of the probe substrate should be considered as well as the potential of the inhibitor to inhibit these.”