Nanostructured materials for applications in drug delivery and tissue engineering

By Michael S. Goldberg, Robert Langer, Xinqiao Jia. Journal of Biomaterials Science. Polymer Edition, 2007

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Treating metastatic cancer with nanotechnology (2011, background): “One proposed mechanism with which to disrupt lysosomes is the proton sponge effect, whereby nanoparticles with cationic surface groups induce osmotic lysis upon endosome acidificatio”
Nanoparticles and microparticles for skin drug delivery. (2011, background): “now be specifically controlled [251] and this has improved our ability to control stability, solubility and drug carrying capacity.”
Techniques for physicochemical characterization of nanomaterials (2013, background): “In a nano-drug delivery system, the system size can influence bioavailability and circulation time in blood stream, partly resulting from the impact of surface area-to-volume ratios on the solubility of the drug delivery systems (Goldberg et al., 2007; Rabinow, 2004; Vinogradov et al., 2002).”
Recent advances of chitosan nanoparticles as drug carriers (2011, methodology): “16,17 Fe 3 O 4 –chitosan nanoparticles were prepared by Qu et al 18 by covalent cross-linking (Figure 2).”
Electrospinning of polymer nanofibers: Effects on oriented morphology, structures and tensile properties (2010, neutral): “These mats resemble the ECM matrix and can be used as skin-scaffold and wound dressing materials where the materials are required to be more elastic than stiff [14,77–82].”