CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs

By L. Shiow, D. Rosen, Naděžda Brdičková, Ying Xu, Jinping An, L. Lanier, J. Cyster, M. Matloubian. Nature, 2006

818 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e7030e694bc8b2a363f031c9e5eb09b7fa49ce67

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Citations in the corpus

Tissue-Resident Memory T Cells (2014, background): “S1PR1 downregulation is concomitantly associated with cell surface expression of the C-type lectin CD69 (Cyster and Schwab, 2012; Matloubian et al., 2004; Schober et al., 1999; Shiow et al., 2006; Skon et al., 2013).”
Immunology of COVID-19: Current State of the Science (2020, neutral): “Cytokines such as IFN-I and TNF-α may inhibit T cell recirculation in blood by promoting retention in lymphoid organs and attachment to endothelium (Kamphuis et al., 2006; Shiow et al., 2006) .”
Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets (2012, neutral): “For example, CD69 upregulation by activated mouse T cells was shown to trigger retention in LN (Shiow et al., 2006).”
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity (2016, background): “A similar expression pattern was observed for CD69, which inhibits egress from lymph nodes (Shiow et al., 2006).”
A molecular cell atlas of the human lung from single cell RNA sequencing (2019, background): “The 58 identified cell populations included 15 epithelial (clusters 1-15), 9 endothelial (16-24), 9 stromal (25-33), and 25 immune (34-58) populations, greater than the number of classical cell types in each compartment (11 epithelial, 5 endothelial, 7 stromal, 20 immune, and 2 neuronal cell types) ”
The mTOR kinase determines effector versus memory cell fate of CD8+ T cells by regulating T-bet and Eomesodermin expression (2010, methodology): “…using markers associated with memory precursor CD8+ T cells, i.e., CD62L (lymph node homing) (Wherry et al., 2003), CD69 (lymph node retention) (Shiow et al., 2006), CD127 (IL-7Ra; essential for memory T cell maintenance) (Schluns et al., 2000), CD122 (IL-15Rb and essential for memory CD8+ T…”