Telomeres and telomerase: their mechanisms of action and the effects of altering their functions

By Elizabeth H Blackburn. FEBS Letters, 2005

823 citations recorded by the source corpus.

The molecular features of telomeres and telomerase are conserved among most eukaryotes. How telomerase and telomeres function and how they interact to promote the chromosome‐stabilizing properties of telomeres are discussed here.

Subfields: Aging, Ecology, Physiology

View Paper: https://www.semanticscholar.org/paper/e6f78cc73194a310234e8a371da8b1f9763bb4f0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. P. Monaghan
2. N. Metcalfe
3. D. Costantini

In Ecology

1. P. Monaghan
2. N. Metcalfe
3. D. Costantini
4. Leif Engqvist
5. Klaus Reinhold

In Physiology

1. P. Monaghan
2. B. Ogretmen
3. N. Metcalfe
4. J. D. Blount

Citations in the corpus

• Telomere length in early life predicts lifespan (2012, background): “In the absence of restoration, telomeres shorten during each round of normal somatic cell division because RNA polymerase cannot completely replicate the lagging strand (3, 4).”
• Roles of bioactive sphingolipids in cancer biology and therapeutics. (2008, background): “Core telomerase contains two main subunits, telomerase reverse transcriptase (hTERT), and the RNA component (hTR), which acts as an intrinsic template (Blackburn, 2005).”
• Oxidative Stress in Aging Human Skin (2015, background): “Senescence is initiated after such dramatic incidences as severe DNA damage, critical telomere shortening, oxidative stress and hyperactive oncogenic RAS [339–342].”
• Evolution of the immune system in humans from infancy to old age (2015, neutral): “Only epithelial lymphocytes and stem cells including haemopoietic (HSCs) express the telomere-lengthen-ing enzyme telomerase in the adult [101], requiring a careful balance against the risk of cancer.”