Acquired and inherited lipodystrophies.

By A. Garg. New England Journal of Medicine, 2004

898 citations recorded by the source corpus.

Lipodystrophies, heterogeneous acquired or inherited disorders characterized by the selective loss of adipose tissue, predispose affected patients to insulin resistance and its attendant complications. This review focuses on the clinical features, underlying pathogenetic mechanisms, and management of various types of acquired and inherited lipodystrophies.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e6d8c5743241d9821862ce5f4620449566027078

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Citations in the corpus

The metabolic syndrome. (2008, background): “The pathogenesis of the lipodystrophies is complex and has been recently reviewed elsewhere (467, 468).”
Pathophysiology of diabetes: An overview (2020, background): “Both these mutations manifest as an autosomal recessive disorder known as Congenital generalized lipoatrophy or Berardinelli-Seip syndrome.[103,104]”
Disordered lipid metabolism and the pathogenesis of insulin resistance. (2007, neutral): “Whilst suppression of fatty acid levels by insulin is consistently impaired in insulin-resistant obese subjects and at least in some forms of lipodystrophy (118), fasting plasma fatty acid levels are not always elevated in insulin-resistant obese subjects (82), nor are they typically elevated in lip”
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution (2010, positive): “Second, the striking abnormalities of regional fat deposition associated with lipodystrophic syndromes demonstrate that genetic variation can have dramatic effects on the development and maintenance of specific fat depots 11 , 12 .”