Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation
By C. Brangwynne, C. Eckmann, D. S. Courson, A. Rybarska, C. Hoege, J. Gharakhani, Frank Jülicher, Anthony A. Hyman. Science, 2009
2,831 citations recorded by the source corpus.
Subfields: Aging, Public Health, Environmental and Occupational Health, Renewable Energy, Sustainability and the Environment
View Paper: https://www.semanticscholar.org/paper/e6d5691e7ef7103c1a65befd3080464cfab3604b
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Citations in the corpus
- Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles (2015, background): “…nucleolus and Cajal bodies indicate that their constituent molecules internally diffuse rapidly (Phair and Misteli, 2000), and P-granules, the worm analog of mammalian nuage or germ granules, condense from a pool of diffuse constituents following specific biological cues (Brangwynne et al., 2009).”
- Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization (2015, positive): “LLPS has been proposed as the molecular mechanism underlying formation of membrane-less cellular bodies that exhibit liquid properties, such as P granules and nucleoli (Brangwynne et al., 2009; Elbaum-Garfinkle et al., 2015; Fromm et al., 2014; Li et al., 2012; Nott et al., 2015).”
- Tau protein liquid–liquid phase separation can initiate tau aggregation (2018, neutral): “…membrane-less organelles have multiple cellular functions, such as p-granule formation to establish intracellular gradients of RNA transcription (Brangwynne et al , 2009), the enrichment of RNA binding proteins in stress granules (Lin et al , 2015; Molliex et al , 2015), concentrating…”
- G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits (2016, background): “…RNA granules (concentration and temperature dependence, and fusion and fission) have led to an evolving “liquid–liquid phase separation” (LLPS) model (Brangwynne et al., 2009; Elbaum-Garfinkle et al., 2015) that posits that RNA granules are composed of immis-cible liquid droplets, held apart from…”
- Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome. (2018, positive): “C as germ (P) granules (Brangwynne et al., 2009), stress granules (Wippich et al.”
- Liquid phase condensation in cell physiology and disease (2017, background): “drip off the surface of a nucleus in response to shear (12).”
- Residue-by-residue view of in vitro FUS granules that bind the C-terminal domain of RNA polymerase II (2015, positive): “…behavior of protein-rich RNP granules and disease-associated inclusions has begun to be elucidated by microscopy both in vitro and in vivo (Brangwynne et al., 2009), the structural and mechanistic details of the protein domains as free monomers, in granule assemblies, and in disease…”
- The role of disordered protein regions in the assembly of decapping complexes and RNP granules (2013, background): “Recent studies shed new light on the specific mechanisms of RNP granule assembly and the role of decapping factors by demonstrating that these granules exhibit characteristics of liquid droplets, and their formation follows the principles of classical liquid–liquid phase separations (Brangwynne et a”