Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme

By D. Harmer, Maureen Gilbert, R. Borman, K. Clark. FEBS Letters, 2002

834 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism, Pharmacology

View Paper: https://www.semanticscholar.org/paper/e62668e1f93552d0ba96dfb33a2f2fa8c8851196

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Citations in the corpus

• Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2 (2005, background): “Tissue expression of the receptor corresponds to the localization of virus in infected individuals and animals (Harmer et al, 2002; Chan et al, 2004; Ding et al, 2004; Hamming et al, 2004) .”
• Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome: Results From a Prospective, Single-Center, Clinicopathologic Case Series (2020, background): “Acute renal tubular injury, which was also reported with SARS-1, seems to be related to hypoxia and causal for terminal renal failure rather than viral induced through the high expression of ACE-2 receptors in the epithelium of the tubules (25, 28).”
• Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS‐CoV) in SARS patients: implications for pathogenesis and virus transmission pathways (2004, methodology): “Analyzing 72 human tissues by real-time PCR, Harmer et al [29] demonstrated that ACE2 is expressed in human lung, gastrointestinal tract, kidney, heart and testis.”
• ACE2 Receptor Expression and Severe Acute Respiratory Syndrome Coronavirus Infection Depend on Differentiation of Human Airway Epithelia (2005, background): “sue, and epithelia of the small intestine and testes (6, 10, 11).”
• Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus (2003, background): “Because both the tissue distribution and subcellular localization of ACE2 are appropriate for a receptor for SARS-Co”
• SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues (2020, positive): “A tissue-level basis for understanding SARS-CoV tropism was proposed based on ACE2 histological staining and expression in human epithelia of the lung and small intestine (Hamming et al., 2004; Harmer et al., 2002; Jonsdottir and Dijkman, 2016).”
• The protein expression profile of ACE2 in human tissues (2020, background): “Early studies based on multi-tissue Northern blotting and QRT-PCR have suggested moderate to high transcript expression of ACE2 in kidney, testis, heart and the intestinal tract, while the expression was low or absent in lung (Harmer et al, 2002; Tipnis et al., 2000).”
• Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis (2004, methodology): “Although real-time PCR revealed that ACE2 mRNA expression is present in 72 human tissues [8], ACE2 protein expression has thus far been identified only in heart, kidney, and testis [9–12].”
• Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2 (2008, background): “Further, human neural cells, including neurons, are infectible by SARS-CoV (54), and neuronal expression of ACE2 has been detected in the human CNS (21).”
• What’s new in the renin-angiotensin system? (2004, background): “Angiotensin(1-7) has been identified as a vasodilator with antidiuretic effects.”
• CT Features of Coronavirus Disease 2019 (COVID-19) Pneumonia in 62 Patients in Wuhan, China. (2020, background): “In addition to respiratory and systemic symptoms of viral infection, some patients with COVID-19 pneumonia presented with a gastrointestinal symptom as the initial symptom; this finding suggests that gastrointestinal symptoms may be associated with the pathogenesis of COVID-19 pneumonia as a result ”
• ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19 (2020, background): “ACE-2 is expressed in a variety of different tissues including both the upper and lower respiratory tract, myocardium and the gastrointestinal mucosa [17].”
• Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes (2009, background): “Another investigation of 72 human tissues by Harmer and his colleagues [10] confirmed ACE2 mRNA expression in bronchus, lung parenchyma, ileum, testis, and cardiovascular, renal, and gastrointestinal tissues, and pancreas.”