Novel crosslinking methods to design hydrogels.

By W. E. Hennink, C. van Nostrum. Advanced Drug Delivery Reviews, 2002

1,405 citations recorded by the source corpus.

Subfields: Biomaterials, Biomedical Engineering, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/e614a65a347d647c55a3ae72a9523888b753628b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

In Biomedical Engineering

In Molecular Medicine

Citations in the corpus

Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering (2005, background): “Of critical importance for cell-containing hydrogels, reaction schemes have been developed that are sufficiently gentle to allow formation in situ , in the presence of cells, just as gels from ECM components are forme”
Chitosan—A versatile semi-synthetic polymer in biomedical applications (2011, background): “The new cross-linking agent, genipin (C11H14O5), is a naturally derived chemical that can bind biological tissues and biopolymers through covalent coupling [185–187].”
Chitosan-based biomaterials for tissue engineering (2013, background): “Both the amino and the hydroxyl groups of chitosan can form a variety of linkages, as amide and ester bonding, but also Schiff base formation [55,75], which can lead to chitosan hydrogels formation.”
Classification, processing and application of hydrogels: A review. (2015, methodology): “Gels prepared using optimized conditions are stable for 6 months at 37 °C [20].”
Morphing in nature and beyond: a review of natural and synthetic shape-changing materials and mechanisms (2016, background): “Properties depend on crosslink density, choice of polymer, copolymer or blend, nature of cross-link bonding [101], and solvent.”
A Review of Three-Dimensional Printing in Tissue Engineering (2016, neutral): “However, chemical cross-linking of many natural materials, such as those derived from extracellular matrix, modifies both the chemical and material properties, and the use of some cross-linking mechanisms is known to pose a detriment to cells, thus decreasing cell viability and functionality.(80) Al”
Crosslinked poly(vinyl alcohol) hydrogels for wound dressing applications: A review of remarkably blended polymers (2015, background): “crystallization of the polymeric chain, hydrogen bond between chains, protein interaction, or design of graft copolymers) (Hennink and Nostrum, 2002).”