Spared nerve injury: an animal model of persistent peripheral neuropathic pain

By I. Decosterd, Clifford J. Woolf. Pain, 2000

2,219 citations recorded by the source corpus.

Subfields: Neurology, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/e613535369effb0c9aaddaf2096f8a2428d28b93

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neurology

1. G. Moalem-Taylor
2. P. Austin
3. J. Scholz
4. Michael R Hamblin
5. Clifford J. Woolf

In Pharmacology

1. Clifford J. Woolf
2. G. Moalem-Taylor
3. P. Austin
4. J. Scholz
5. K. Moore
6. Michael R Hamblin
7. T. Kohno
8. R. Ji

In Physiology

1. Clifford J. Woolf
2. G. Moalem-Taylor
3. P. Austin
4. J. Scholz
5. R. Meyer
6. J. Campbell
7. K. Moore
8. T. Kohno

Citations in the corpus

• The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines. (2010, positive): “peroneal sciatic nerve branches are ligated, but the sural nerve is left intact (Decosterd and Woolf, 2000).”
• TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. (2006, positive): “Unilateral spared nerve injury was done by exposing the sciatic nerve in the thigh region of the mouse, cutting and ligating the tibial and common peroneal nerves, and leaving the remaining sural nerve intact (Decosterd and Woolf, 2000).”
• Mesenchymal Stem Cells for Regenerative Medicine (2019, background): “For nerve regeneration studies, sciatic nerve crush and nerve gap animal models were established [131,132], and the effects of local implantation [133] or intravenous administration [134,135] of neural stem cells or MSCs in peripheral nerve injury models have been investigated, resulting in excellen”
• Methods Used to Evaluate Pain Behaviors in Rodents (2017, background): “In this model, the lateral plantar skin of the hind paw, which is the area of innervation of the sural nerve, has the greatest reduction in mechanical thresholds compared to other innervation areas of the plantar skin (Decosterd and Woolf, 2000).”
• Attenuated cold sensitivity in TRPM8 null mice. (2007, positive): “The use of topical acetone-induced evaporative cooling is commonly employed to assess cold allodynia in rats following nerve injury (Choi et al., 1994; Decosterd and Woolf, 2000).”
• Mechanisms of neuropathic pain. (2006, background): “In the spared nerve injury (SNI) model, the common peroneal and tibial nerves are cut, sparing the sural nerve (Decosterd and Woolf, 2000).”
• Towards a theory of chronic pain (2008, neutral): “In contrast, in the spared nerve injury model (Decosterd and Woolf, 2000) where the tibial and peroneal branches of the sciatic nerve are cut, stable and peak thermal hyperalgesia and mechanical allodynia are only observed at about 2 weeks after the initial injury.”
• Partial Peripheral Nerve Injury Promotes a Selective Loss of GABAergic Inhibition in the Superficial Dorsal Horn of the Spinal Cord (2002, methodology): “The primary afferent-evoked currents in lamina II neurons were recorded in slices from naive rats and after three types of peripheral nerve injury, complete sciatic nerve transection (SNT), CCI (Bennett and Xie, 1988), and spared nerve injury (SNI) (Decosterd and Woolf, 2000).”
• Mechanisms and applications of the anti-inflammatory effects of photobiomodulation (2017, background): “This involves ligating two out of three branches of the sciatic nerve in rats and causes long lasting (>6 months) mechanical allodynia [77].”