Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway.

By A. Brunet, Sandeep R. Datta, Michael E. Greenberg. Current Opinion in Neurobiology, 2001

1,200 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e5fb008bdabfee40694ad1a702f4e0771d2d1ff3

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In Molecular Biology

Citations in the corpus

Regulation of Dendritic Morphogenesis by Ras–PI3K–Akt–mTOR and Ras–MAPK Signaling Pathways (2005, background): “In a simplified scheme, it can be generalized that PI3K–Akt via mTOR plays a central role in growth control by controlling ribosomal biogenesis and activity of the translation machinery, whereas other downstream effectors play dominant roles in cell survival through phosphorylation of the cytoskelet”
Control of Dendritic Arborization by the Phosphoinositide-3′-Kinase–Akt–Mammalian Target of Rapamycin Pathway (2005, background): “The production of PIP3 by PI3K induces a myriad of cellular responses in neurons, such as transcription (Brunet et al., 2001), translation (Akama and McEwen, 2003), protein trafficking (Lhuillier and Dryer, 2002; Man et al.”
Forkhead transcription factors: key players in development and metabolism. (2002, background): “Forkhead proteins of the FoxO subfamily are targets for PI3K/PDK1/PKB signaling initiated by insulin or insulinlike growth factor I receptors (for reviews, see Brunet et al., 2001; Kops and Burgering, 1999).”
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. (2006, neutral): “…PI3K-Akt signaling pathway leads to the activation of DAF-16 and thereby promotes life-span extension in nematodes, inhibition of this signaling pathway and consequent activation of FOXO transcription factors triggers cell death in mammalian cells (Brunet et al., 2001; Kenyon, 2005).”
Remote Excitation of Neuronal Circuits Using Low-Intensity, Low-Frequency Ultrasound (2008, background): “signaling pathway is capable of blocking cell death and promoting cell survival of many neuronal cell types [55].”
Neurotrophin-regulated signalling pathways (2006, background): “In collaboration with phosphoinositide-dependent kinases, they activate the protein kinase Akt, which in turn controls through phosphorylation the activities of several proteins important in promoting cell survival (Yuan & Yankner 2000; Brunet et al. 2001; Yuan et al. 2003a).”