Coordinated transcription of key pathways in the mouse by the circadian clock.

By Satchidananda Panda, M. Antoch, B. H. Miller, Andrew I. Su, Andrew B. Schook, Martin Straume, Peter G. Schultz, Steve A. Kay, J. Takahashi, John B. Hogenesch. Cell, 2002

2,370 citations recorded by the source corpus.

In mammals, circadian control of physiology and behavior is driven by a master pacemaker located in the suprachiasmatic nuclei (SCN) of the hypothalamus. We have used gene expression profiling to identify cycling transcripts in the SCN and in the liver. Our analysis revealed approximately 650 cycling transcripts and showed that the majority of these were specific to either the SCN or the liver. Genetic and genomic analysis suggests that a relatively small number of output genes are directly regulated by core oscillator components. Major processes regulated by the SCN and liver were found to be under circadian regulation. Importantly, rate-limiting steps in these various pathways were key sites of circadian control, highlighting the fundamental role that circadian clocks play in cellular and organismal physiology.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Plant Science

View Paper: https://www.semanticscholar.org/paper/e5afb402fcd7ec22606f641b5a40b4f78af98272

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Citations in the corpus

Harmonics of Circadian Gene Transcription in Mammals (2009, methodology): “Collection of liver time points was performed as previously described [14].”
Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. (2006, background): “Since different tissues have characteristic sets of genes with clock-regulated timing and amplitude of expression (Panda et al. 2002a; Storch et al. 2002), it is likely that the circadian clock is involved in control of homeostasis in different organs.”
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice (2005, background): “Importantly, previous transcriptome analysis in the SCN and liver of Clock mutant mice has uncovered global changes in metabolic pathways, including those encoding enzymes of glycolysis, mitochondrial oxidative phosphorylation, and lipid metabolism [21].”
Circadian regulator CLOCK is a histone acetyltransferase. (2006, positive): “About 10% of all mammalian transcripts undergo circadian fluctuations in abundance (Akhtar et al., 2002; Duffield et al., 2002; Panda et al., 2002).”
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “Regulation of circadian expression of RORs As mentioned above, in several tissues RORs display a rhythmic expression during the circadian cycle [Liu et al., 2008; Panda et al., 2002; Sato et al., 2004; Ueda et al., 2002b; Ueda et al., 2005; Ukai-Tadenuma et al., 2008].”
Molecular components of the mammalian circadian clock. (2006, background): “The identification of the circadian transcripts has revealed that the transcriptional circadian regulation extends beyond core clock components to include various clock-controlled genes (CCGs), including key regulators for cell cycle and metabolism ( 60 ,61).”