CNS energy metabolism as related to function.

By A. Ames. Brain research. Brain research reviews, 2000

674 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e4c04bc9608fcf79706a8051bc70333f3ceea40c

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In Cellular and Molecular Neuroscience

In Molecular Biology

Citations in the corpus

The neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signal. (2002, background): “5 ml of oxygen per 100 g of brain tissue per minute (Siesjo 1978; Ames 2000).”
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway (2014, background): “The majority of ATP is generated through OXPHOS, therefore implying the strict reliance of neuronal activity on mitochondria functionality and oxygen supply (Ames, 2000; Erecinska, Cherian & Silver, 2004).”
Astrocyte glycogen and brain energy metabolism (2007, background): “…of glycogen in brain, compared with liver, is also consistent with the simple reality that the rigid skull limits fluctuations in intracranial contents; massive up and down regulation of bulk glycogen would simply not be possible without disruptive changes in intracranial pressure (Ames, 2000).”
Modeling the hemodynamic response to brain activation. (2004, neutral): “Indeed, the action of the sodium–potassium pump is thought to consume a large fraction of the ATP energy budget in the brain (Ames, 2000).”
Mitochondria and neuronal activity. (2007, background): “Since most neuronal ATP is generated by oxidative metabolism, neurons critically depend on mitochondrial function and oxygen supply (1, 60, 144).”
Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients (2006, background): “Both of these changes increase Na influx into the axon, which is normally exchanged for extracellular K by the Na /K ATPase in a rapid and energydependent manner.(31) We speculate that this exchange is impaired in chronically demyelinated axons because the upper motor neuron supplies it with dysfunc”
On the nature of the BOLD fMRI contrast mechanism. (2004, background): “The cerebral metabolic rate (CMR) is commonly expressed in terms of oxygen consumption (CMRO2) because glucose metabolism is about 90% aerobic and therefore parallels oxygen consumption [84,85].”