Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition

By Nancy Julien, P. Goffaux, P. Arsenault, Serge Marchand. Pain, 2005

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Prediction of chronic post‐operative pain: Pre‐operative DNIC testing identifies patients at risk (2008, background): “Recent evidence indicates that patients with idiopathic pain disorders, such as temporo-mandibular disorders, fibromyalgia, tension headache, migraine and irritable bowel syndrome, demonstrate lower DNIC efficiency [12,16,20,25,30].”
The influence of negative emotions on pain: Behavioral effects and neural mechanisms (2009, positive): “pain syndromes accompanied by depressive symptoms such as fibromyalgia might be explained by a lack of descending inhibition or spinal hyperexcitability (Julien et al., 2005; Klauenberg et al., 2008).”
Neuropathic Pain (2009, background): “…autonomous amplification of nociceptive signals inside the CNS (Nielsen et al. 2008, Staud & Rodriguez 2006) with a disturbed balance of excitation and inhibition in central circuits ( Julien et al. 2005) and altered sensory processing that can be detected by functional imaging (Staud et al. 2008).”
Models and mechanisms of hyperalgesia and allodynia. (2009, background): “The mechanisms of generalized facilitation of nociception may have relevance for some human pain patients as it has been suggested that in fibromyalgia patients endogenous pain modulatory systems are impaired (223).”