Compartmentalization of Mammalian folate-mediated one-carbon metabolism.
By Anne S. Tibbetts, D. Appling. Annual review of nutrition, 2010
637 citations recorded by the source corpus.
Subfields: Biochemistry, Clinical Biochemistry, Rheumatology
View Paper: https://www.semanticscholar.org/paper/b9ff25d790e004ad748330e8a97a532c0c4a25a6
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In Biochemistry
In Clinical Biochemistry
In Rheumatology
Citations in the corpus
- One-Carbon Metabolism in Health and Disease. (2017, methodology): “Mitochondrial NAD+/NADH ratios are maintained by oxidative phosphorylation, and early experiments in isolated mitochondria showed that formate production from serine was respiration dependent (Garcı́a-Martı́nez and Appling, 1993).”
- Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. (2013, background): “One-Carbon Metabolism One-carbon (1C) transfer reactions are essential for amino acid catabolism; transfer of methyl groups to DNA, RNA, and proteins; and in formylation of the initiator transfer RNA (tRNA) required for mitochondrial protein synthesis (Tibbetts and Appling, 2010).”
- Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. (2012, positive): “CH2-THF contains the methylene group that fuels de novo thymidine synthesis from deoxyuridine in concert with pyrimidine biosynthesis and hence nucleotide synthesis during cell proliferation (Tibbetts and Appling, 2010).”