Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.

By Alexander S. Hebert, Kristin E. Dittenhafer-Reed, Wei Yu, Derek J. Bailey, E. Selen, M. Boersma, J. J. Carson, Marco Tonelli, Allison J. Balloon, Alan J Higbee and 7 more. Molecules and Cells, 2013

643 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/ed3afa7a59785a89d734fc32e78ad52574fc2651

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

1. John C. Newman
2. T. Arnesen
3. Rasmus Ree
4. Adrian Drazic
5. Line M. Myklebust
6. E. Verdin
7. M. Hirschey

In Molecular Biology

1. Patrycja Puchalska
2. P. Crawford
3. E. Verdin
4. Matthew P. Jacobson
5. Yue Chen
6. M. Larance
7. Angus I. Lamond
8. L. Gray

In Physiology

1. Christopher B. Newgard
2. John C. Newman
3. Patrycja Puchalska
4. P. Crawford
5. E. Verdin
6. M. Hirschey

Citations in the corpus

• Multidimensional proteomics for cell biology (2015, background): “An interesting aspect to the property of protein turn over rate is that newly synthesized proteins must undergo many changes to become fully functional, including proper folding and often PTMs and binding to other proteins.”
• Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics (2017, background): “A large number of dynamically acetylated mitochondrial proteins, many of which may occur through nonenzymatic mechanisms, have also emerged from computational proteomics studies (Dittenhafer-Reed et al., 2015; Hebert et al., 2013; Rardin et al., 2013; Shimazu et al., 2010).”
• SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways (2013, background): “Acetylation is a major regulator of most or all metabolic pathways in amanner that is conserved from bacteria to mammals (Finley et al., 2011; Hallows et al., 2011; Hebert et al., 2013; Hirschey et al., 2011; Smith et al., 2011; Starai et al., 2002; Wang et al., 2010; Zhang et al., 2009; Zhao et al.”
• Regulation of pyruvate metabolism and human disease (2013, background): “More recently, mitochondrial proteome studies have identified a hydroxylation site and multiple acetylation sites on PC [45, 46].”
• SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks (2013, positive): “This raises a question as to what mechanism is responsible for the widespread but specific lysine acylation of mitochondrial proteins that we and others have identified (Hebert et al., 2013; Kim et al., 2006; Rardin et al., 2013).”
• The world of protein acetylation. (2016, background): “Neutral or acidic residues next to the acetylated lysinemake it less available to SIRT3, and as a result these siteswere unaffected by Sirt3 KO [337,338].”
• Lysine Glutarylation Is a Protein Post-Translational Modification Regulated by SIRT5 (2014, methodology): “Our bioinformatic analyses showed that Kglu is highly enriched with metabolic processes, such as cellular respiration, and fatty acid and amino acid metabolism, similar to what has been observed for acetylation and succinylation (Chen et al., 2012; Hebert et al., 2013; Park et al., 2013).”