Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair

By I. Bock-Marquette, A. Saxena, Michael D. White, J. Dimaio, Deepak Srivastava. Nature, 2004

686 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d05aea40a3a04c45e640daa243ba6f34cc89345a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Deepak Srivastava

In Cell Biology

1. K. Legate

In Molecular Biology

1. K. Legate
2. Deepak Srivastava
3. B. Bruneau

Citations in the corpus

• ILK, PINCH and parvin: the tIPP of integrin signalling (2006, background): “Thymosin-β4 binds to LIM domains -4 and -5 of PINCH1, upregulates ILK activity and positively influences migration and survival of cardiac cell”
• Making or breaking the heart: from lineage determination to morphogenesis. (2006, background): “Thymosin β4, a 43-amino-acid secreted peptide, contains an actin binding domain that is abundantly expressed in the developing heart, where it can regulate cell migration events during morphogenesis (Bock-Marquette et al., 2004).”
• Evidence supporting paracrine hypothesis for Akt‐modified mesenchymal stem cell‐mediated cardiac protection and functional improvement (2006, positive): “The direct injection of thymosin 4h as recently been reported to limit myocardial infarct size and to induce functional recovery in the same experimental model used in our study ( 28 ).”