ILK, PINCH and parvin: the tIPP of integrin signalling

By K. Legate, Eloi Montañez, O. Kudlacek, Reinhard Füssler. Nature reviews. Molecular cell biology, 2006

725 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6f010953385d639fe31e341221af6ac44dcc4c4d

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Citations in the corpus

Integrins and extracellular matrix in mechanotransduction. (2010, background): “Kinase activities of integrin-linked kinase are uncertain as the kinase domain lacks catalytic residues that are normally conserved among protein kinases; however in vitro studies suggest there may be some catalytic activity, though this has not been identified in vivo.(41) Paxillin acts as an adapt”
Genetic and cell biological analysis of integrin outside-in signaling. (2009, background): “Additional connections between ILK and the cytoskeleton can also form through paxillin, which in turn binds to parvin and vinculin (Legate et al. 2006).”
E-cadherin–integrin crosstalk in cancer invasion and metastasis (2013, background): “This promotes dynamic actin and adhesion changes at the cell membrane, and activation of numerous downstream signalling pathways that have a pivotal function in cellular processes, such as adhesion, migration, proliferation and survival (Cabodi et al., 2010; Legate et al., 2006).”
SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. (2008, background): “A preformed complex consisting of the three proteins, ILK, PINCH, and Parvin, represents an important component of the integrin adhesion complex (Legate et al., 2006).”
EMT, the cytoskeleton, and cancer cell invasion (2009, background): “Integrins are linked to the actin cytoskeleton and signal via the ternary complex of integrin-linked kinase (ILK), pinch and parvin, also named the tIPP complex [107] (Fig.”
Integrin Structure and Function (2010, background): “Cdc42 activity has been shown to be regulated by Src activity and ligand binding to integrins can activate Cdc42 via the ILK–Pinch–parvin complex (Legate et al. 2006).”