Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis: The Importance of Lesion Stage and Phagocytic Efficiency

By I. Tabas. Arteriosclerosis, Thrombosis and Vascular Biology, 2005

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The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models (2008, background): “Overloading the phagocytic capacity of macrophages to clear apoptotic cells might in turn lead to secondary necrosis, which would perpetuate inflammation and plaque instabilit”
Role of cholesterol and lipid organization in disease (2005, background): “In this regard, there is evidence for defective phagocytic clearance of apoptotic macrophages in advanced atherosclerotic lesions, which leads to post-apoptotic necrosis of the cell”
Monocyte-Macrophages and T Cells in Atherosclerosis (2017, positive): “A lesional-macrophage resolution process that has received particular attention in the field of atherosclerosis is efferocytosis (Tabas, 2005; Schrijvers et al., 2007; Linton et al., 2016; Van Vré et al., 2012).”