Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication
By Kei-ichi Nakayama, Hiroyasu Nagahama, Y. A. Minamishima, M. Matsumoto, Ikuo Nakamichi, K. Kitagawa, M. Shirane, R. Tsunematsu, T. Tsukiyama, N. Ishida and 3 more. EMBO Journal, 2000
774 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/e3799efe92baaedd2e76b59ff403e597b16c0078
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Citations in the corpus
- The role of hepatocytes and oval cells in liver regeneration and repopulation. (2003, background): “…is a complex step that can be modulated by various agents, including Bcl-2, which slows down the hepatocyte cell cycle in the regenerating liver (Vail et al., 2002) as well as Skp2, an Fbox protein component of an ubiquitin ligase that degrades the p27 cell cycle inhibitor (Nakayama et al., 2000).”
- The F-box protein family (2000, background): “References can be obtained from [10], with the exception of the more recent references for LIN-23 [34], centrosome overreplication in Slimb mutants [35], and the substrates Met4 [36], Gcn4 [37], cyclin E [38], and p27KIP1 [25,38-40].”
- Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer (2008, background): “In agreement with biochemical data acquired in cultured cells, the absence of SKP2 in mice results in the accumulation of p27, and Skp2 −/− mice were shown to be smaller than wild-type littermate”
- Phosphorylation‐dependent degradation of c‐Myc is mediated by the F‐box protein Fbw7 (2004, background): “Mice lacking Skp2 manifest cellular accumulation of cyclin E and p27Kip1 as well as overreplication of chromosomes and centrosomes (Nakayama et al, 2000).”