Exosomal microRNA: a diagnostic marker for lung cancer.

By G. Rabinowits, Ç. Gerçel-Taylor, J. Day, D. Taylor, G. Kloecker. Clinical Lung Cancer, 2008

1,278 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e3555ad92fa8bee40f3b305c258bc9617da8688f

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Citations in the corpus

Extracellular vesicles: Exosomes, microvesicles, and friends (2013, background): “Later studies reported on the RNA contents of EV isolates from other cell cultures (Skog et al., 2008) and from body fluids (Hunter et al., 2008; Rabinowits et al., 2009; Michael et al., 2010).”
Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. (2010, background): “More evidence reveals that miRNAs are present in microvesicles.(16,26,27) It remains to be seen whether cardiac-origin miRNAs released from damaged myocardium are in the form of microvesicles when they enter into circulating blood.”
microRNA as Biomarkers and Diagnostics (2016, background): “Exosomal miRNAs have been detected in the peripheral blood and culture media of several cell lines (Valadi et al., 2007; Taylor and Gercel-Taylor, 2008) and might be useful for development of biomarkers associated with adenocarcinoma (Rabinowits et al., 2009).”
Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche. (2011, background): “Recently, circulating MVs were described in patient with various tumors (27-32) suggesting that they may serve as diagnostic and prognostic tool (33-35).”
Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “Exosomes derived from biopsy specimens and serum samples serve as biomarkers for ovarian and lung cancer diagnosis [210,211].”
Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, positive): “Later on, a number of groups proposed the use of exosomal miRNAs for diagnostic and prognostic purposes in lung [117], glioblastoma [118], esophageal squamous cell carcinoma [119], prostate [120, 121], ovarian [122], breast [123], colon [124], kidney [125], leukemia [126], and other types of cancer ”
Characterization of human plasma-derived exosomal RNAs by deep sequencing (2013, background): “While exosomes have been shown to play functional roles in recipient cells, the RNA content of the exosomes may provide unique molecular signatures for disease diagnosis and prognosis [9,36-39].”
Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function (2015, methodology): “It is of note that some exosomal miRNAs can be used to aid in clinical diagnosis ( Table 1 ) [29,30,54,62].”
Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery. (2014, background): “Due to their cell specific origin, MVs in the blood may even serve as biomarkers for diseases [53,54].”